ABT-751 is an orally bioavailable tubulin-binding agent that is currently under clinical development for cancer treatment. In preclinical studies, ABT-751 showed antitumor activity against a broad spectrum of tumor lines including those resistant to conventional chemotherapies. In this study, we investigated the antivascular properties of ABT-751 in a rat subcutaneous tumor model using dynamic

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ABT-751 (E 7010) is a novel bioavailable tubulin-binding and antimitotic sulfonamide agent with IC50 of about 1.5 and 3.4 μM in neuroblastoma and non-neuroblastoma cell lines, respectively. For research use only. We do not sell to patients. ABT-751 Chemical Structure Hande The pharmacokinetics and safety of ABT-751, a novel, orally bioavailable sulfonamide antimitotic agent: results of a phase 1 study.

ABT-751 downregulated stable/phospho-SKP2 including pSKP2(S64) and pSKP2(S72), which targeted cyclin-dependent kinase inhibitors for degradation through the inactivation of AKT. Our results suggested that ABT-751 may act as an anti-cancer drug by inhibiting cell migration, invasion yet inducing cell cycle arrest, autophagy and apoptosis in distinct UBUC-derived cells.

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Buy ABT 751 (CAS 141430-65-1), an inhibitor of microtubule polymerization, from Santa Cruz. Molecular Formula: C18H17N3O4S, Molecular Weight: 371.41 Article Title: Pharmacokinetics of orally administered ABT-751 in children with neuroblastoma and other solid tumors Article Snippet: ..The glucuronide and sulfate metabolites of ABT-751 were measurable in plasma 30 min after the dose and plasma concentration of the sulfate peaked at a median of 3 h post-dose and the glucuronide peaked at 5 h. ABT-751(E 7010) is a novel bioavailable tubulin-binding and antimitotic sulfonamide agent with IC50 of about 1.5 and 3.4 μM in neuroblastoma and non-neuroblastoma cell lines, respectively.
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A tubulin polymerisation inhibitor; binds to the colchicine binding site on β-tubulin (Ki = 3.3 µM); inhibits tubulin polymerisation in a concentration-dependent manner; inhibits growth of 26 human tumor cell lines (IC50s = 0.06-0.08 µg/ml); induces tumor regression in NB-1382 neuroblastoma, IRS56 rhabdomyosarcoma, and KT-6 Wilms mouse Find and order inhibitors and products like this ABT-751 (E7010) on www.antibodies-online.com. Order product ABIN4875004.

References. 1. Use of abt-751 ABT-751(E 7010) is a novel bioavailable tubulin-binding and antimitotic sulfonamide agent with IC50 of about 1.5 and 3.4 μM in neuroblastoma and non-neuroblastoma cell lines, respectively.IC50 Value: 1.5 μM(neuroblastoma); 3.4 μM(non-neuroblastoma)Target: Microtubule/Tubulinin vitro: ABT-751 shows the selective cytotoxicity with IC50 of 0.6–2.6 μM in neuroblastoma and 0.7 ABT-751 (also known as E7010) is a novel, potent and orally bioavailable antimitotic sulfonamide agent/tubulin inhibitor with IC50 of about 1.5 and 3.4 μM in neuroblastoma and non-neuroblastoma cell lines, respectively.
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2002, 24:751-757. [11C]MPA compared with [11C]ABT-418 and (S)(-)[11C]nicotine in rhesus John Whiley and Sons, Chichester, pp 751-756 (1997).

Margareta Göransdotter Abt. 1615 in Grangärde (W). 2731 Brita Persdotter, born Abt. 1615 in Ludvika, Grangärde (W); died 28 Apr 1661 in Ancestry: SJ 751 AB 04 / ABT 06 (bifogas ej).

ABT-751 (E7010) binds to the colchicine site on β-tubulin and inhibits polymerization of microtubules, not a substrate for the MDR transporter and is active against cell lines resistant to vincristine, doxorubicin, and cisplatin. Phase 1/2. Selleck's ABT-751 (E7010) has been cited by 5 publications J Clin Invest, 2020, 10.1172/JCI122462

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Duration (Months) 1.8 NCI's Dictionary of Cancer Terms provides easy-to-understand definitions for words and phrases related to cancer and medicine.